Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced primarily by placental trophoblasts during pregnancy. It is composed of two noncovalently associated subunits, an α-subunit and a β-subunit. The β-subunit confers much of the hormone's biological and immunological specificity.

The hCG β-core fragment (β-core) is a major urinary degradation product derived primarily from the β-subunit of hCG. It is generated through proteolytic processing of hCG and related β-subunit forms and can be present at significant levels in urine, particularly during pregnancy. Because the β-core fragment shares structural features with the hCG β-subunit, antibodies specifically recognizing β-core epitopes are valuable tools for studying hCG metabolism and degradation products.

Anti-human hCG β-core antibodies specifically recognize epitopes within the β-core fragment and are useful for the detection and characterization of this hCG-related analyte. Depending on the antibody's specificity and validation, these antibodies may be used in immunoassays, including ELISA, lateral-flow assays, and other diagnostic or analytical platforms. Anti-hCG β-core antibodies are particularly valuable in studies of hCG metabolism, pregnancy-related biomarkers, and the development of assays for the detection of hCG-related molecular forms.