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   Antibody De Novo Sequencing

ProtTech is providing one of the world best quality antibody de novo sequencing services. With as low as 100ug of a mAb protein, we can deliver a complete and accurate mAb protein sequences with distinguished leucine and isoleucine residues.  We guarantee a 100% accuracy of delivered mAb sequences. If the expressed mAb with our delivered sequences has lower activity than the original mAb in ELISA assay, we’ll continue our effect to identify possible sequence errors free of charge.

Please contact us for your protein analysis inquiry or request.

Application of antibody de novo sequencing service:

  1. The development of bio-similar antibody for diagnostic or therapeutic use.

  2. The development of antibody drugs based on commercially available antibody reagents. Some commercially available antibody reagents may have neutralizing activity toward a drug target. Direct sequencing such a reagent antibody may offer a good starting point for further development such as affinity maturation and humanization.

  3. Resolving ambiguity from mAb gene sequencing. Due to the higher error rate in RT-PCR and technical difficulty in mAb gene sequencing itself, it is not rare that the result from mAb gene sequencing has ambiguity. The mAb protein sequencing is a faster and cost-saving way to resolve sequence conflict.