PD-L1-ProtTech Inc.

  
     
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PD-L1
Recombinant human PD-L1/CD274, extracellular domain is produced in E. coli. The final protein sequence contains F19-H240 of human PD-L1 fused to a polyhistidine tag on the carboxyl terminus.
  • Name: PD-L1
  • Synonyms: Programmed cell death 1 ligand 1, PDCD1 ligand 1
  • Catalogue Number:PT-OP-0001
  • Application:Research in immunotherapy
  • Price: 100ug $120.00 500ug $500.00 1mg $900.00
  • Number:
  • Concentration:0.5mg/ml
  • Store:Avoid repeated freeze-thaw cycles. 12 months at -20 C to -80 C. 1 month at 2 C to 8 C.

Description: Recombinant human PD-L1/CD274, extracellular domain is produced in E. coli. The final protein sequence contains F19-H240 of human PD-L1 fused to a polyhistidine tag on the carboxyl terminus.


Background: PD-L1 is a ligand for program cell death 1 (PD1). PD-L1 suppresses immune response against tumor cells upon binding to PD1 receptor. PD-L1 is expressed on T and B cells, macrophages, dendritic cells, and some nonimmune cells. Binding of PD-L1 to its receptor, PD1 on the surface of T cells resultes in deactivation of T cells. Blockade of PD-1 or PD-L1 by specific antibodies leads to enhanced antitumor immunity of T cells.


Sequence :MPGFTVTVPK DLYVVEYGSN MTIECKFPVE KQLDLAALIV YWEMEDKNII QFVHGEEDLK VQHSSYRQRA RLLKDQLSLG NAALQITDVK LQDAGVYRCM ISYGGADYKR ITVKVNAPYN KINQRILVVD PVTSEHELTC QAEGYPKAEV IWTSSDHQVL SGKTTTTNSK REEKLFNVTS TLRINTTTNE IFYCTFRRLD PEENHTAELV IPELPLAHPP NERTHHHHHH

 

Accession #: Q9NZQ7

 

Quality control: Verified by disulfide mapping and Mass Spectrometry analyses.


Product Source: PD-L1 was produced in E. coli cells transformed with the coding sequence of the extracellular domain of human PD-L1 gene.

Usage: FOR LABORATORY RESEARCH USE ONLY.

 

References:

  1. Hamanishi, Junzo, et al. "Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human      ovarian cancer." Proceedings      of the National       Academy of Sciences 104.9 (2007): 3360-3365.

  2. Lin, David Yin-wei, et al. "The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors." Proceedings of the National Academy of Sciences 105.8 (2008): 3011-3016.

 

Cat No.: PT-OP-0001
Product Name: PD-L1
Type: Protein
Property:
Origin:
Source: E.coli
Application: Research in immunotherapy
Formulation: Sterile filtered through a 0.2 micron filter in 20 mM Tris buffer at pH8.
Purity: >95% by SDS-PAGE gel
Storage: Avoid repeated freeze-thaw cycles. 12 months at -20 C to -80 C. 1 month at 2 C to 8 C.
Limitation:
Note: