Product Description: PD-1 receptor is a single immunoglobulin variable like domain that inducibly expressed on the surface of natural killer cells, B cells, activated monocytes, CD4+ T cells and CD8+ T cells. PD-1 expression is induced by T cell receptor or B cell receptor. PD-1 interaction with its ligands, PD-L1 and PD-L2, regulate the threshold for T cell activation and cytokines production.

Sequence:.MPGWFLDSPD RPWNPPTFSP ALLVVTEGDN ATFTCSFSNT SESFVLNWYR MSPSNQTDKL AAFPEDRSQP GQDCRFRVTQ LPNGRDFHMS VVRARRNDSG TYLCGAISLA PKAQIKESLR AELRVTERRA EVPTAHPSPS PRPAGQFQTL VGSHHHHHH

Accession #: Q15116

Quality control: Verified by disulfide mapping and Mass Spectrometry analysis.

Product Source: PD1 was produced in E. coli cells transformed with human PD1 gene. This product is sterile and does not contain any components of animal origin.

Usage: FOR LABORATORY RESEARCH USE ONLY.

References:

1. Sharpe,      Arlene H., E. John Wherry, Rafi Ahmed, and Gordon J. Freeman. "The      function of programmed cell death 1 and its ligands in regulating      autoimmunity and infection." Nature      immunology 8, no. 3      (2007): 239-245.

2. Brown,      Julia A., David M. Dorfman, Feng-Rong Ma, Elizabeth L. Sullivan, Oliver      Munoz, Clive R. Wood, Edward A. Greenfield, and Gordon J. Freeman.      "Blockade of programmed death-1 ligands on dendritic cells enhances T      cell activation and cytokine production." The Journal of Immunology 170, no. 3 (2003): 1257-1266.