Product Description: PD-1 receptor is a single immunoglobulin variable like domain that inducibly expressed on the surface of natural killer cells, B cells, activated monocytes, CD4+ T cells and CD8+ T cells. PD-1 expression is induced by T cell receptor or B cell receptor. PD-1 interaction with its ligands, PD-L1 and PD-L2, regulate the threshold for T cell activation and cytokines production.
Sequence:.MPGWFLDSPD RPWNPPTFSP ALLVVTEGDN ATFTCSFSNT SESFVLNWYR MSPSNQTDKL AAFPEDRSQP GQDCRFRVTQ LPNGRDFHMS VVRARRNDSG TYLCGAISLA PKAQIKESLR AELRVTERRA EVPTAHPSPS PRPAGQFQTL VGSHHHHHH
Accession #: Q15116
Quality control: Verified by disulfide mapping and Mass Spectrometry analysis.
Product Source: PD1 was produced in E. coli cells transformed with human PD1 gene. This product is sterile and does not contain any components of animal origin.
Usage: FOR LABORATORY RESEARCH USE ONLY.
Sharpe, Arlene H., E. John Wherry, Rafi Ahmed, and Gordon J. Freeman. "The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection." Nature immunology 8, no. 3 (2007): 239-245.
Brown, Julia A., David M. Dorfman, Feng-Rong Ma, Elizabeth L. Sullivan, Oliver Munoz, Clive R. Wood, Edward A. Greenfield, and Gordon J. Freeman. "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production." The Journal of Immunology 170, no. 3 (2003): 1257-1266.
|Application：||Research in immunotherapy|
|Formulation：||Sterile filtered through a 0.2 micron filter in 50% glycerol, 10 mM MES buffer at pH 6.5|
|Purity：||>95% by SDS-PAGE gel|
|Storage：||Avoid repeated freeze-thaw cycles. 12 months at -20 C to -80 C. 1 month at 2 C to 8 C.|