PD-1-ProtTech Inc.

  
     
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PD-1
Recombinant human PD-1, extracellular domain is produced in E. coli. The final protein sequence contains G22-V170 of human PD1 fused to a polyhistidine tag on the carboxyl terminus.
  • Name: PD-1
  • Synonyms: PD1, PDCD1, programmed cell death 1
  • Catalogue Number:PT-OP-0002
  • Application:Research in immunotherapy
  • Price: 100ug $200.00 200ug $380.00 1000ug $1700.00
  • Number:
  • Concentration:0.4mg/ml
  • Store:Avoid repeated freeze-thaw cycles. 12 months at -20 C to -80 C. 1 month at 2 C to 8 C.

Product Description: PD-1 receptor is a single immunoglobulin variable like domain that inducibly expressed on the surface of natural killer cells, B cells, activated monocytes, CD4+ T cells and CD8+ T cells. PD-1 expression is induced by T cell receptor or B cell receptor. PD-1 interaction with its ligands, PD-L1 and PD-L2, regulate the threshold for T cell activation and cytokines production.


Sequence:.MPGWFLDSPD RPWNPPTFSP ALLVVTEGDN ATFTCSFSNT SESFVLNWYR MSPSNQTDKL AAFPEDRSQP GQDCRFRVTQ LPNGRDFHMS VVRARRNDSG TYLCGAISLA PKAQIKESLR AELRVTERRA EVPTAHPSPS PRPAGQFQTL VGSHHHHHH


Accession #: Q15116

 

Quality control: Verified by disulfide mapping and Mass Spectrometry analysis.

 

Product Source: PD1 was produced in E. coli cells transformed with human PD1 gene. This product is sterile and does not contain any components of animal origin.


Usage: FOR LABORATORY RESEARCH USE ONLY.


References:

  1. Sharpe,      Arlene H., E. John Wherry, Rafi Ahmed, and Gordon J. Freeman. "The      function of programmed cell death 1 and its ligands in regulating      autoimmunity and infection." Nature      immunology 8, no. 3      (2007): 239-245.

  2. Brown,      Julia A., David M. Dorfman, Feng-Rong Ma, Elizabeth L. Sullivan, Oliver      Munoz, Clive R. Wood, Edward A. Greenfield, and Gordon J. Freeman.      "Blockade of programmed death-1 ligands on dendritic cells enhances T      cell activation and cytokine production." The Journal of Immunology 170, no. 3 (2003): 1257-1266.

Cat No.: PT-OP-0002
Product Name: PD-1
Type: Protein
Property:
Origin:
Source: E.coli
Application: Research in immunotherapy
Formulation: Sterile filtered through a 0.2 micron filter in 50% glycerol, 10 mM MES buffer at pH 6.5
Purity: >95% by SDS-PAGE gel
Storage: Avoid repeated freeze-thaw cycles. 12 months at -20 C to -80 C. 1 month at 2 C to 8 C.
Limitation:
Note: